Salt: Aminophylline
Therapeutic Description: Bronchodilators & Anti-asthma Preps: Orals/Parenterals
Category: Xanthine.
Pregnancy: Risk cannot be ruled out.
Lactation: Caution advised or effect undetermined.
Contraindications: Porphyria.
Precautions: Cardiac or liver diseases, hypertension, hyperthyroidism, peptic ulceration, epilepsy, fever, hypokalaemia risk, avoid in acute porphyria.
Reversible airways obstruction, severe acute asthma.
Plasma-theophylline concentration for optimum response 10-20 mg/Litre (55-110 micro mol/litre); measure plasma-theophylline concentrate 4-6 hours after dose by mouth and at least 5 days after starting oral treatment; measure plasma-theophylline concentration 4-6 hours after the start of intravenous infusion; narrow margin between therapeutic and toxic dose
INJECTION: Severe acute asthma or acute exacerbation of chronic obstructive pulmonary disease in patients not previously treated with theophylline: Adults: By slow IV injection over at least 20 min (with close monitoring), 250-500 mg (5 mg/kg), then adjusted according to requirement
Dilute with IV fluid to a conc. of 1 mg/mL and infuse over 20-30 min; maximum conc: 25 mg/mL; maximum rate of infusion: 0.36 mg/kg/min, and not greater than 25 mg/min.
Compatibility: D5W, NS.
Cimetidine, erythromycin, sympathomimetics in children, ciprofloxacin, interferon.
Nausea, gastric irritation, headache, CNS stimulation, hypotension, arrhythmias, and convulsions especially if given rapidly by IV injection.
Strength Pack Size PKR
250 mg5 Ampx10 mL84.72

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