Salt: Co-amoxiclav
Therapeutic Description: Broad-spectrum Penicillins
Category: Beta-lactamase inhibitor/broad-spectrum penicillin.
Pregnancy: No evidence of risk in humans.
Lactation: Caution advised or effect undetermined.
Contraindications: Penicillin hypersensitivity, history of co-amoxiclav-associated or penicillin associated jaundice or hepatic dysfunction.
Precautions: Hepatic impairment (monitor hepatic function). Risk of crystalluria with high doses, patient should be well hydrated. Do not dilute Syp below half- strength.
Infections of the respiratory tract, ENT, UTI, skin and soft tissue.
ORAL: Susp 156.25 mg: Children: Under 3 months, not recommended; 3-9 months, 2.5 mL half-strength; 9 months-2 years, 5 mL half-strength. 2-6 years, 5 mL. All three times daily for up to fourteen days, then review.
Susp 312.5 mg: Children: 6-12 years, 5 mL. All three times daily for up to fourteen days, then review.
Tab: In mild to moderate infections: Adults: 375 mg three times daily or 625 mg two times dail
By direct IV push over a period of 3-4 min used within 20 min of reconstitution. By IV intermittent infusion over 30-40 min and complete within 4 hours of reconstitution.
Anticoagulants, allopurinol, probenecid, oral contraceptives, methotrexate.
Hepatitis, cholestatic jaundice, erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis, exfoliative dermatitis, vasculitis, rarely prolongation of bleeding time, dizziness, headache, convulsions (particularly with high doses or in renal impairment), superficial staining of teeth with suspension, phlebitis at injection site.
Strength Pack Size PKR
62.5 mg20 mL130.00
1.2 gm10 Vial1559.02
600 mg1 Vial79.80
156.25 mg60 mL70.00
312.5 mg60 mL109.00
457 mg35 mL75.00
457 mg70 mL142.00
1 gm6's179.10
375 mg6's82.00
625 mg6's120.00

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