Pregnancy: Positive evidence of risk: Use only when no safer alternative exists for a serious problem.
Lactation: Caution advised or effect undetermined.
Contraindications: Previous or active peptic ulceration, haemophilia and other bleeding disorders. Severe renal or hepatic impairment Children under 16 years unless specifically indicated (e.g., for Kawasaki's disease).
Precautions: Aspirin/anti-inflammatory induced allergies, history of bronchospasm, asthma, uncontrolled hypertension, mild to moderate renal function, renal or hepatic impairment, dehydration, G6PD deficiency. Not recommended for treatment of gout. Elderly; avoid continuous prolonged use.
Prevention of secondary thrombotic cerebrovascular or cardiovascular disease, and following surgery. Mild to moderate pain.
Stroke/TIA: Adults: 50-325 mg once daily.
Suspected AMI: Adults: Initial: 160-162.5 mg once daily as soon
Oral anticoagulants, heparin, antiplatelet agents, fibrinolytics, NSAIDs, uricosuric agents, methotrexate, SSRls, venlafaxine, corticosteroids, acetazolamide.
Bronchospasm, GI upset, allergic reactions, GI and other haemorrhage. Tinnitus, vertigo, confusion, increased bleeding.