Glucophage

Salt: Metformin
Therapeutic Description: Hypoglycaemics excluding Insulins
Category: Biguanide.
Pregnancy: No evidence of risk in humans.
Lactation: Contraindicated or not recommended.
Contraindications: Diabetic ketoacidosis or precoma, renal or hepatic impairment. Acute conditions predisposing to renal impairment. Cardiac or respiratory failure, recent MI, alcoholism. Administration of iodinated contrast materials. Discontinue for 48 hours before and after elective surgery.
Precautions: Assess risk factors for lactic acidosis; discontinue immediately if metabolic acidosis suspected. Monitor renal function at least annually.
Maturity-onset diabetes either alone or with sulphonylureas. Adjuvant therapy in insulin-dependent diabetes, particularly in the obese.
Adults: Initial 500 mg twice daily or 850 mg daily with meals. Titrate: Increase by 500 mg every week, or 850 mg every two weeks, or from 500 mg twice daily to 850 mg twice daily every 2 weeks. Max: 2550 mg daily.
With Insulin: Adults: Initial: 500 mg daily. Titrate: 500 mg eve
Alcohol, iodinated contrast agents, diuretics, corticosteroids, ACE inhibitors, cimetidine.
GI upset, taste disturbance, rarely lactic acidosis, abnormal liver function tests, hepatitis, skin reactions, reduced B12 absorptions.
Strength Pack Size PKR
1 gm5x10's118.40
250 mg5x10's73.45
500 mg5x10's75.67
850 mg3x10's60.69

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