Pregnancy: Risk cannot be ruled out.
Lactation: Contraindicated or not recommended.
Precautions: Monitor patients every 6 months for hepatitis B biochemical, virological and serological markers to determine the treatment duration. Renal impairment. Monitor renal function every 3 months. Cirrhosis; monitor closely for hepatic decompensation. Monitor patients closely for several months after stopping therapy for acute exacerbations of hepatitis. Patients (particularly obese women) with hepatomegaly, hepatitis, other risk factors of liver disease; risk of lactic acidosis, sometimes fatal. Co-infection with hepatitis C or D or HIV. Elderly.
Treatment of chronic hepatitis B in adults with compensated liver disease with evidence of ALT levels and histological evidence of active liver inflammation and fibrosis. Tre
Drugs excreted by or which affect renal tubular excretion.
GI upset, asthenia, abdominal pain, headache, raised serum creatinine levels, renal insufficiency, renal failure.