Salt: Topotecan
Therapeutic Description: Cytostatics
Category: Topoisomerase 1 inhibitor.
Pregnancy: Contraindicated in pregnancy.
Lactation: Contraindicated or not recommended.
Contraindications: Severe myelosuppression.
Precautions: Renal or hepatic impairment. Mild to moderate renal impairment. Ensure baseline neutrophils as necessary prior to treatment. Monitor blood regularly.
Metastatic ovarian cancer where other therapies have failed.
Adults: 1-5 mg per m² daily by IV infusion o
Administer IVP Bolus over 30 min or by 24 hours continuous inf.
Reconstitution: Reconstitute vials with 4 mL SWFI, D5W or NS; may be further diluted in 50-100 mL D5W or NS for inf.
Neutropenia, thrombocytopenia, anaemia, abdominal pain, fatigue, asthenia.
Strength Pack Size PKR
4 mg5 Vial117135.72

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