Dose as Anticonvulsant: Partial/primary generalized tonic-clonic/generalized seizures of Lennox-Gastaut syndrome: Adults & Children: >12 years: Concomitant Valproate (VPA): Wk 1&2: 25 mg od/day. Wk 3&4: 25 mg/day. Wk 5 Onward: Increase by 25-50 mg/day every 1-2 wk. Maintenance: 100-200 mg/day if VPA alone or 100-400 mg/day if VPA with other drugs including glucuronidation (od/bid doses). Not taking these enzymes-inducing anti-epileptic drugs (EIAEDs) (Carbamazepine, Phenytoin, Phenobarbital, Primidone) or VPA: Wk 1&2: 25 mg/day. Wk 3 & 4: 50 mg/day. Wk 5 Onward: Increase by 50 mg/day every 1-2 wk. Maintenance: 225-375 mg/day (in bid doses). Concomitant EIAEDs without VPA: Wk 1 & 2: 50 mg/day. Wk 3&4: 100 mg/day (bid doses). Wk 5 Onward: Increase by 100 mg/day every 1-2 wk. Maintenance: 300-500 mg/day (bid doses). 2-12 years: <
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