Salt: Lamotrigine
Therapeutic Description: Anti-epileptics
Category: Triazine.
Pregnancy: Risk cannot be ruled out.
Lactation: Contraindicated or not recommended.
Contraindications: Significant hepatic impairment.
Precautions: Monitor hepatic, renal & clotting parameters in patients who develop rash, fever, flu, drowsiness or worsening of seizure control. Withdraw gradually over 2 weeks.
Monotherapy for partial, primary and secondarily generalized tonic-clonic seizures. Add-on therapy for partial and secondary generalized tonic-clonic seizures. Prevention of depressive episodes associated with bipolar disorder.
Dose as Anticonvulsant: Partial/primary generalized tonic-clonic/generalized seizures of Lennox-Gastaut syndrome: Adults & Children: >12 years: Concomitant Valproate (VPA): Wk 1&2: 25 mg od/day. Wk 3&4: 25 mg/day. Wk 5 Onward: Increase by 25-50 mg/day every 1-2 wk. Maintenance: 100-200 mg/day if VPA alone or 100-400 mg/day if VPA with other drugs including glucuronidation (od/bid doses). Not taking these enzymes-inducing anti-epileptic drugs (EIAEDs) (Carbamazepine, Phenytoin, Phenobarbital, Primidone) or VPA: Wk 1&2: 25 mg/day. Wk 3 & 4: 50 mg/day. Wk 5 Onward: Increase by 50 mg/day every 1-2 wk. Maintenance: 225-375 mg/day (in bid doses). Concomitant EIAEDs without VPA: Wk 1 & 2: 50 mg/day. Wk 3&4: 100 mg/day (bid doses). Wk 5 Onward: Increase by 100 mg/day every 1-2 wk. Maintenance: 300-500 mg/day (bid doses). 2-12 years: <
Phenytoin, carbamazepine, phenobarbitone, primidone, sodium valproate.
Headache, tiredness, insomnia, GI disturbances, rash, including angioedema and Stevens-Johnson syndrome, diplopia, blurred vision, dizziness, ataxia, tremor, agitation, confusion, irritability, aggression.
Strength Pack Size PKR
100 mg30's1896.29
25 mg30's668.82
50 mg30's1115.99

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