Pregnancy: No evidence of risk in humans.
Lactation: Caution advised or effect undetermined.
Contraindications: Recent GI surgery, GI obstruction, perforation or haemorrhage, prolactin-dependent breast carcinoma, pheochromocytoma.
Precautions: Renal or hepatic impairment, porphyria.
Dyspepsia, flatulence, regurgitation of bile, heartburn and other symptoms of upper Gl tract dysfunction. Nausea and vomiting due to gastro-intestinal disorders, intolerance to cytotoxic drugs, congestive heart failure, post- operative conditions, deep X-ray or cobalt therapy.
Adults: 20 years and over: 10 mg three times daily orally, IM or IV. Usual max 0.5 mg/kg body-wt daily.
Children & Young Adul
Injection solution may be given IM, direct IV push, short infusion (15-30 min), or continuous infusion; lower doses (?10 mg) of metoclopramide can be given IV push undiluted over 1-2 min; higher doses to be given IVPB over at least 15 min.
Compatibility: Stable in D5 1/2NS, LR, NS, mannitol 20%.
Anticholinergics, phenothiazines, butyrophenones, tetrabenazine, levodopa, bromocriptine, pergolide, narcotic analgesic, aspirin, paracetamol.
Extrapyramidal reactions, neuroleptic malignant syndrome. Raised serum prolactin leading to galactorrhoea, irregular periods and gynaecomastia. Drowsiness, diarrhoea, rash.