Salt: Fluphenazine
Therapeutic Description: Tranquilizers, Sedatives/Hypnotics
Category: Phenothiazine.
Pregnancy: Risk cannot be ruled out.
Lactation: Caution advised or effect undetermined.
Contraindications: Pheochromocytoma, renal or hepatic failure, marked cerebral atherosclerosis, severe cardiac insufficiency, comatose states, severe depression, blood dyscrasias.
Precautions: Liver, respiratory or cardiac disease, cardiac arrhythmias, thyrotoxicosis, epilepsy, glaucoma, hypothyroidism, myasthenia gravis, prostatic hypertrophy. Parkinson's disease; reduce dose or use anti-Parkinsonian drugs in patients showing extra-pyramidal reactions. Very hot weather. Elderly.
Maintenance treatment of psychotic disorders particularly schizophrenia.
INJECTION: Adults: Initially 12.5 mg by deep IM inj into gluteal region to test susceptibility to extra-pyramidal reactions, then adjust dose according to response. Usual dosage range, 12.5 mg to 100 mg every two to five weeks.
Administered by IM injection.
Stability: Intact vials should be stored at controlled room temperature and protected from freezing and light. Solutions that are darker than light amber, are discoloured in some other way, or contain a precipitate should not be used.
Adrenaline, alcohol, barbiturates, CNS depressants, other antipsychotics, anticholinergics, antacids, dopaminergics, lithium, oral hypoglycaemics, antihypertensives, anticonvulsants, drugs that prolong the QT interval (e.g. anti-arrhythmics), sibutramine, metoclopramide.
Leucopenia, hyperprolactinaemia, acute dystonias and dyskinesias, akathisia, Parkinsonism, drowsiness, insomnia, agitation, tachycardia, arrhythmias, ECG changes, hypotension, anticholinergic effects (e.g. dry month, blurred vision), respiratory depression, nasal stuffiness, rash, photosensitivity, hyperglycaemia, impaired temperature regulation, male sexual dysfunction. Rarely, agranulocytosis, tardive dyskinesia, jaundice, neuroleptic malignant syndrome, pigmentary retinopathy.
Strength Pack Size PKR
25 mg1 Ampx1 mL114.06

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