Pregnancy: Positive evidence of risk: Use only when no safer alternative exists for a serious problem.
Lactation: Caution advised or effect undetermined.
Contraindications: Pheochromocytoma, renal or hepatic failure, marked cerebral atherosclerosis, severe cardiac insufficiency, comatose states, severe depression, blood dyscrasias. Heart block, arrhythmias, mania, severe hepatic impairment. Porphyria.
Precautions: Liver, respiratory or cardiac disease, cardiac arrhythmias, thyrotoxicosis, epilepsy, glaucoma, hypothyroidism, myasthenia gravis, prostatic hypertrophy. Parkinson's disease; reduce dose or use anti-Parkinsonian drugs in patients showing extra-pyramidal reactions. Very hot weather. Epilepsy, concurrent ECT, hyperthyroidism, psychosis. Suicidal tendencies. Anaesthesia. Withdraw gradually. Elderly.
Mild to moderate mixed anxiety/depression.
Adults: 1 tab two to
Adrenaline, alcohol, barbiturates, CNS depressants, other antipsychotics, anticholinergics, antacids, dopaminergics, lithium, oral hypoglycaemics, antihypertensives, anticonvulsants, drugs that prolong the QT interval (e.g. anti-arrhythmics), sibutramine, metoclopramide, sympathomimetics, carbamazepine, barbiturates, cimetidine.
Leucopenia, hyperprolactinaemia, acute dystonias and dyskinesias, akathisia, Parkinsonism, drowsiness, insomnia, agitation, tachycardia, arrhythmias, ECG changes, hypotension, anticholinergic effects (e.g. dry month, blurred vision), respiratory depression, nasal stuffiness, rash, photosensitivity, hyperglycaemia, impaired temperature regulation, male sexual dysfunction. Rarely, agranulocytosis, tardive dyskinesia, jaundice, neuroleptic malignant syndrome, pigmentary retinopathy.