Lactation: Contraindicated or not recommended.
Contraindications: Ensure adequate contraception in childbearing women.
Precautions: Moderate to severe hepatic impairment (Child-Pugh score more or equal to 7). Risk factors for thromboembolism. Obtain peripheral blood smear and complete blood count, serum ALT, AST and bilirubin before and during treatment. East Asian patients, elderly.
Chronic immune thrombocytopenic purpura in splenectomised patients refractory to other treatments. Second line treatment for non-splenectomised patients wh
Methotrexate, statins, topotecan, antacids, dairy products, mineral supplement, lopinavir, ritonavir, corticosteroids, danazol, azathioprine, IV immunoglobulins.
Insomnia, headache, paraesthesia, cataract, dry eye, GI upset, altered LFTs, skin reactions, alopecia, arthralgia, myalgia, muscle spasm, bone pain, fatigue, peripheral oedema, thrombotic/thromboembolic complications.