Salt: Co-trimoxazole
Therapeutic Description: Trimethoprim & Combinations
Category: Folic acid inhibitor/sulphonamide.
Pregnancy: Contraindicated in pregnancy.
Lactation: Contraindicated or not recommended.
Contraindications: Neonates. Severe renal or hepatic insufficiency. Blood dyscrasias.
Precautions: Elderly. Renal impairment (reduce or space out dosage). Severe allergy or asthma. Folate or G6PD deficiency. Perform regular haematological tests during long term therapy. Discontinue if rash develops. Maintain adequate urinary output.
Infections of respiratory, gastro-intestinal, urinary tracts and skin.
Adults: 2 tab of 80/400 mg or 1 tab of 160/800 mg or 20 mL of 40/200 mg or 10 mL of 80/400 mg susp twice daily.
Children: Susp 40/200 mg: Under 6 weeks, not recommended; 6 weeks-5 months,
Folate inhibitors, anticoagulants, anticonvulsants, hypoglycaemics, cyclosporin, procainamide, amantadine, lamivudine, thiazides, pyrimethamine, digoxin.
Nausea, vomiting, glossitis, skin rashes. Blood dyscrasias. Folate deficiency. Liver changes. Rarely erythema multiforme, Lyell syndrome, exfoliative dermatitis. Stevens-Johnson syndrome, convulsions, peripheral neuritis, ataxia.
Strength Pack Size PKR
80/400 mg50 mL30.00
160/800 mg100's291.47
40/200 mg50 mL21.00
80/400 mg400's643.59

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