Salt: Bupropion
Therapeutic Description: Other CNS Drugs
Category: Dopamine-reuptake inhibitor, antidepressant.
Pregnancy: Contraindicated in pregnancy.
Lactation: Contraindicated or not recommended.
Contraindications: History of seizures, bipolar disorder, bulimia, anorexia nervosa, CNS tumour, patients experiencing abrupt withdrawal of alcohol or benzodiazepines. Severe hepatic cirrhosis.
Precautions: Risk of seizure increased in patients with history of head trauma, alcohol abuse or diabetes; only use if compelling clinical justification and use a lower dose of 150 mg daily throughout treatment period. Mild to moderate hepatic or renal impairment. Monitor BP before and during treatment, especially in patients with pre-existing hypertension. Monitor BP weekly if using concomitant transdermal nicotine. History of psychiatric illness. Elderly.
Aid to smoking cessation.
Adults: Initially 150 mg daily for 6 days, increase to 150 mg twice daily allowing minimum 8 hours between doses. Maximum single dose, 150 mg; maximum daily dose, 300 mg. Start treatment while still smoking
MAOIs, antipsychotics, antidepressants, antimalarials, tramadol, theophylline, systemic steroids, sedating antihistamines, quinolones, beta-blockers, classic antiarrhythmics. Alcohol or benzodiazepine withdrawal. Central stimulants, anorectic agents, drugs metabolised by CYP2D6, 1A2 or 2B6. Carbamazepine, phenytoin, valproate, levodopa.
Insomnia, headache, fever, dry mouth, GI upset, CNS effects, skin/hypersensitivity reactions, taste disorders, tremor, dizziness, concentration disturbance.
Strength Pack Size PKR
150 mg30's750.00
300 mg30's1380.00

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