Salt: Acyclovir, Inf and Oral
Therapeutic Description: Antivirals, Systemics
Category: Nucleoside analogue.
Pregnancy: No evidence of risk in humans.
Lactation: Caution advised or effect undetermined.
Precautions: Renal impairment. Maintain hydration. Elderly.
Herpes simplex, varicella-zoster. See under dosage.
ORAL: Herpes simplex treatment: Adults: 200 mg (400 mg in the immunocompromised or if absorption impaired) 5 times daily, usually for 5 days. Children: Under 2 years, half adult dose; over 2 years, same as adult dose.
Herpes simplex, prevention of recurrence: Adults: 200 mg 4 times daily or 400 mg twice daily possibly reduced to 200 mg 2 or 3 times daily and interrupted every 6-12 months.
Herpes simplex, prophylaxis in the immunocompromised: Adults: 200-400 mg 4 times daily. Children: Under 2 years, half adult dose; over 2 years, same as adult dose.
Varicella and herpes zoster, treatment: Adults: 800 mg 5 times daily for 7 days. Children: Varicella: 20 mg/kg (
Avoid rapid infusion; infuse over 1 hour to prevent renal damage; maintain adequate hydration; check for phlebitis and rotate infusion sites.
Probenecid, cimetidine.
Rash, photosensitivity, headache, dizziness, confusion, hallucinations, somnolence, convulsions. Rarely transient elevation of liver enzymes, blood urea and creatinine, acute renal failure, hepatitis, jaundice, decrease in haematological indices.
Strength Pack Size PKR
250 mg5 Amp2377.03
200 mg5x5's1749.50

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